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Younus, Mohsen
- Effect of Celastrus Paniculatus on Learning, Memory and Serum Biochemistry of Aging Albino Rats
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1 Department of Chemistry, Singhania University, Pacheri Bari, Distt. Jhunjhunu, Rajasthan-333515, IN
1 Department of Chemistry, Singhania University, Pacheri Bari, Distt. Jhunjhunu, Rajasthan-333515, IN
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International Journal of Chemistry and Chemical Engineering, Vol 3, No 1 (2013), Pagination: 1-5Abstract
Ethanol extract of Celastrus paniculatus was administered at the rate of 2g/kg body weight orally 16 days before trial experiment in male Wister albino rats of 3, 12 and 20 months old animals. They were studied for learning and memory process as well as for any change in the serum biochemistry. All animals were trained on Y-maze. Each animal received a daily session of 10 trials for 5 days i.e. a maximum of 50 trials. Increase in response of 5th session as compared to 1st session was taken as criteria of learning and memory. There was a significant increase in learning and memory in the treated group with respect to its control. Results show that Celastrus paniculatus preferentially affects learning and recall of memory and also regulate the serum biochemistry.Keywords
Learning, Memory, Serum, Y-MazeReferences
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- Antioxidant and Anti-Alzheimer Activity of Celastrus paniculatus Seed
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Authors
Affiliations
1 Vitalife Laboratories Ltd, Gurgaon, Haryana-(122001), IN
2 Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh-(284001), IN
1 Vitalife Laboratories Ltd, Gurgaon, Haryana-(122001), IN
2 Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh-(284001), IN
Source
International Journal of Chemistry and Chemical Engineering, Vol 3, No 1 (2013), Pagination: 29-36Abstract
The crude methanolic extract of the seeds of Celastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and antialzheirmer (AD) activity. The extracts showed prominent DPPH free radical scavenging activity, inhibiting activity of authentic peroxynitrite (ONOO-) and inhibition of total reactive oxygen species (ROS) generation. In DPPH radical scavenging assay, the EtOAc fraction showed the highest activity with a IC50 value of 25.92±1.02 μg/ml whereas aqueous fractions had no activity at all within the tested concentration. Scavenging of the authentic ONOO- system, all extract/fractions showed good activity and among them, EtOAc fraction had the highest activity with a IC50 value of 15.79±0.18 μg/ml. EtOAc fraction also showed significant (p<0.001) inhibitory activity against the total ROS generation which was almost similar with that of the positive control Trolox (IC50 16.79±0.19 μg/ml). All extract/fractions exhibited statistically significant (p<0.001) cholinesterases (ChEs) inhibitory effects with IC50 values ranging between 134.7-227.5 μg/ml for AChE and 209.6-562.1 μg/ml for BChE.Keywords
Anti-Alzheimer, Antioxidant, Cholinesterase, Celastrus Paniculatus, ROSReferences
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